STK26 Gene Summary [Human]
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | STK26 |
| Official Name | serine/threonine kinase 26 [Source:HGNC Symbol;Acc:HGNC:18174] |
| Ensembl ID | ENSG00000134602 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 26, STE20-like kinase 4 |
| Synonyms | 2610018G03Rik, MASK, MST4, RP6-213H19.1, serine/threonine kinase 26 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- epithelial cancer
- organismal death
- colorectal cancer
- Huntington disease
- HER2 negative hormone receptor negative breast cancer
- dilated cardiomyopathy
- gastrointestinal neoplasia
- hepatocellular carcinoma
role in cell
- proliferation
- apoptosis
- expression in
- cell viability
- quantity
- phosphorylation in
- synthesis in
- growth
- differentiation
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- Golgi Apparatus
- cytosol
- vesicle membrane
- apical membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- microvillus assembly
- protein autophosphorylation
- cellular response to oxidative stress
- regulation of apoptotic process
- cellular response to starvation
- protein phosphorylation
- negative regulation of cell migration
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- vesicle membrane
- membrane
- cytosol
- Golgi apparatus
- apical plasma membrane
- Golgi-associated vesicle
- cell periphery
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- protein kinase activity
- protein serine/threonine kinase activity