SIKE1 Gene Summary [Human]
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SIKE1 |
| Official Name | suppressor of IKBKE 1 [Source:HGNC Symbol;Acc:HGNC:26119] |
| Ensembl ID | ENSG00000052723 |
| Bio databases IDs | |
| Aliases | suppressor of IKBKE 1, suppressor of IKK epsilon |
| Synonyms | 2810005O12Rik, 5730470L24RIK, AI450236, RGD1311316, RP5-1000E10.4, SIKE, Sikeb, suppressor of IKBKE 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIKE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- SIKE family
- protein binding activity, bridging
- enzyme binding
- coiled-coil domain
- protein binding
Pathways
Biological processes and signaling networks where the SIKE1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
role in cell
- activation in
- binding in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIKE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- small GTPase binding
- protein binding, bridging