STMN3 Gene Summary [Human]
This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | STMN3 |
| Official Name | stathmin 3 [Source:HGNC Symbol;Acc:HGNC:15926] |
| Ensembl ID | ENSG00000197457 |
| Bio databases IDs | |
| Aliases | stathmin 3 |
| Synonyms | 9330161A03RIK, SCLIP, stathmin 3, stathmin-like 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STMN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding
- stathmin-like domain
- protein domain specific binding
- protein binding
- stathmin domain
- chaperone binding
- Stathmin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial cancer
- cancer
- prostate cancer
- prostatic carcinoma
- systemic autoimmune syndrome
- breast carcinoma
- metastasis
- schizophrenia
- soft tissue sarcoma
regulates
- cyclic AMP
- tubulin
role in cell
- proliferation
- accumulation in
- migration
- motility
- organization
- morphology
- depolymerization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STMN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- regulation of cytoskeleton organization
- blastocyst hatching
- regulation of GTPase activity
- negative regulation of Rac protein signal transduction
- nervous system development
- regulation of microtubule polymerization or depolymerization
- cytoplasmic microtubule organization
- microtubule depolymerization
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytoplasm
- cytosol
- Golgi apparatus
- neuron projection
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein domain specific binding
- protein binding