PLEKHA7 Gene Summary [Human]
Enables delta-catenin binding activity. Involved in epithelial cell-cell adhesion; pore complex assembly; and zonula adherens maintenance. Located in several cellular components, including centrosome; nucleoplasm; and zonula adherens. Part of pore complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLEKHA7 |
| Official Name | pleckstrin homology domain containing A7 [Source:HGNC Symbol;Acc:HGNC:27049] |
| Ensembl ID | ENSG00000166689 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing A7 |
| Synonyms | A430081P20RIK, AI414265, LOC100047292, LOC100289201, LOC100289918, LOC100292788, LOC283278, pleckstrin homology domain containing A7, pleckstrin homology domain containing, family A member 7, RGD1304650 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLEKHA7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prefoldin subunit
- Domain with 2 conserved Trp (W) residues
- afadin binding domain
- prefoldin
- WW
- PH domain
- protein binding
- Pleckstrin homology-like domain
- WW domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Alzheimer disease
- pneumonia
- glaucoma
- open-angle glaucoma
- schizophrenia
- coronary artery disease
- insomnia
- cleft lip
- microalbuminuria
role in cell
- expression in
- cell death
- migration
- invasion by
- formation
- formation in
- accumulation in
- assembly
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- centrosome
- intercellular junctions
- cell-cell contacts
- cytosol
- nucleoplasm
- zonula adherens
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLEKHA7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell-cell adhesion
- cell-cell adhesion mediated by cadherin
- pore complex assembly
- zonula adherens maintenance
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- zonula adherens
- pore complex
- cytosol
- cell junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- delta-catenin binding
- protein binding