Stmn3 Gene Summary [Mouse]
Enables protein domain specific binding activity. Involved in several processes, including cytoplasmic microtubule organization; negative regulation of Rac protein signal transduction; and neuron projection development. Acts upstream of or within blastocyst hatching. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human STMN3 (stathmin 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stmn3 |
| Official Name | stathmin-like 3 [Source:MGI Symbol;Acc:MGI:1277137] |
| Ensembl ID | ENSMUSG00000027581 |
| Bio databases IDs | |
| Aliases | stathmin-like 3 |
| Synonyms | 9330161A03RIK, SCLIP, stathmin 3, stathmin-like 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stmn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding
- stathmin-like domain
- protein domain specific binding
- protein binding
- stathmin domain
- chaperone binding
- Stathmin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial cancer
- cancer
- prostate cancer
- prostatic carcinoma
- systemic autoimmune syndrome
- breast carcinoma
- metastasis
- schizophrenia
- soft tissue sarcoma
regulates
- cyclic AMP
- tubulin
role in cell
- proliferation
- accumulation in
- migration
- motility
- organization
- morphology
- depolymerization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stmn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- regulation of cytoskeleton organization
- blastocyst hatching
- regulation of GTPase activity
- negative regulation of Rac protein signal transduction
- nervous system development
- regulation of microtubule polymerization or depolymerization
- cytoplasmic microtubule organization
- microtubule depolymerization
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytoplasm
- cytosol
- Golgi apparatus
- neuron projection
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein domain specific binding
- protein binding