NKIRAS1 Gene Summary [Human]
Predicted to enable GTPase activating protein binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NKIRAS1 |
| Official Name | NFKB inhibitor interacting Ras like 1 [Source:HGNC Symbol;Acc:HGNC:17899] |
| Ensembl ID | ENSG00000197885 |
| Bio databases IDs | |
| Aliases | NFKB inhibitor interacting Ras like 1 |
| Synonyms | 2400004O09Rik, kappaB-Ras1, KBRAS1, NFKB inhibitor interacting Ras-like 1, NFKB inhibitor interacting Ras-like protein 1, κ b-ras 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NKIRAS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain-switch II region
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NKIRAS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung alveolus development
- Ral protein signal transduction
- regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- surfactant homeostasis
Cellular Component
Where in the cell the gene product is active
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- GTP binding
- GTPase activity
- GTPase activating protein binding