AKR1B10 Gene Summary [Human]
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AKR1B10 |
| Official Name | aldo-keto reductase family 1 member B10 [Source:HGNC Symbol;Acc:HGNC:382] |
| Ensembl ID | ENSG00000198074 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1 member B10, aldose reductase-like 1, aldo-keto reductase family 1, member B11 (aldose reductase-like), aldose reductase-like peptide, aldose reductase-related protein, small intestine reductase |
| Synonyms | 2310005E10RIK, AKR1B11, AKR1B12, aldo-keto reductase family 1 member B10, ALDRLn, ARL-1, HIS, HSI |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AKR1B10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- activation domain
- Aldo-keto reductase (AKR) superfamily
- indanol dehydrogenase
- aldo-keto reductase
- retinal dehydrogenase
- CH-OH group:NAD or NADP oxidoreductase
- Aldo/keto reductase family
- enzyme
- protein binding
- geranylgeranyl reductase
- alcohol dehydrogenase (NADP)
Pathways
Biological processes and signaling networks where the AKR1B10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- lung cancer
- organismal death
- acne
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- gastric cancer
- cancer
- colorectal cancer
role in cell
- expression in
- apoptosis
- proliferation
- cell viability
- migration
- invasion by
- signaling in
- adhesion
- invasiveness
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- lysosome
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AKR1B10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinoid metabolic process
- daunorubicin metabolic process
- retinol metabolic process
- doxorubicin metabolic process
- farnesol catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- indanol dehydrogenase activity
- protein binding
- NADP-retinol dehydrogenase activity
- geranylgeranyl reductase activity
- retinal dehydrogenase activity
- alditol:NADP+ 1-oxidoreductase activity
- allyl-alcohol dehydrogenase activity
- aldo-keto reductase (NADP) activity
- alcohol dehydrogenase (NADP+) activity