AKR1B15 Gene Summary [Human]
Enables estradiol 17-beta-dehydrogenase activity. Predicted to be involved in estrogen biosynthetic process. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | AKR1B15 |
| Official Name | aldo-keto reductase family 1 member B15 [Source:HGNC Symbol;Acc:HGNC:37281] |
| Ensembl ID | ENSG00000227471 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1 member B15 |
| Synonyms | AKR1B10L, AKR1B10L, AK1R1B7, AKR1R1B7, aldo-keto reductase family 1 member B15 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AKR1B15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- estradiol 17beta-dehydrogenase
- Aldo-keto reductase (AKR) superfamily
- CH-OH group:NAD or NADP oxidoreductase
- Aldo/keto reductase family
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the AKR1B15 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AKR1B15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen biosynthetic process
- retinol metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- NADP-retinol dehydrogenase activity
- testosterone 17-beta-dehydrogenase (NADP+) activity
- alditol:NADP+ 1-oxidoreductase activity
- allyl-alcohol dehydrogenase activity
- farnesol dehydrogenase activity