ADH4 Gene Summary [Human]
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ADH4 |
| Official Name | alcohol dehydrogenase 4 (class II), pi polypeptide [Source:HGNC Symbol;Acc:HGNC:252] |
| Ensembl ID | ENSG00000198099 |
| Bio databases IDs | |
| Aliases | alcohol dehydrogenase 4 (class II), pi polypeptide |
| Synonyms | Ac1002, ADH-1, ADH-2, ADH class iv, alcohol dehydrogenase 4 (class II), pi polypeptide, alcohol deshydrogenase 4, HEL-S-4, LOC100364917 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADH4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alcohol dehydrogenase
- MDR
- retinol binding
- Zinc-binding dehydrogenase
- benzaldehyde dehydrogenase (NAD)
- enzyme
- protein binding
- NADPH:quinone reductase
- NAD or NADH binding
- zinc ion binding
- all-trans retinal binding
- retinol dehydrogenase
- Alcohol dehydrogenase GroES-like domain
- aldehyde or oxo group:NAD or NADP oxidoreductase
- aldehyde reductase
Pathways
Biological processes and signaling networks where the ADH4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- insomnia
- alcoholism
- esophageal carcinoma
- esophageal carcinoma formation
- hepatocellular carcinoma
- acute myeloid leukemia
- dementia
- progressive familial intrahepatic cholestasis type 1
regulates
- 20-hydroxyeicosatetraenoic acid
- retinol
- aldehyde
- retinoid
- 9-cis-retinol
- alitretinoin
- alcohol
- retinaldehyde
- tretinoin
- quinone derivative
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADH4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- alcohol catabolic process
- cellular aldehyde metabolic process
- formaldehyde catabolic process
- retinoid metabolic process
- retinol metabolic process
- alcohol metabolic process
- ethanol metabolic process
- fatty acid omega-oxidation
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- alditol:NADP+ 1-oxidoreductase activity
- alcohol dehydrogenase (NAD) activity
- alcohol dehydrogenase activity, zinc-dependent
- NADPH:quinone reductase activity
- all-trans retinal binding
- retinol dehydrogenase activity
- protein binding
- NAD binding
- S-(hydroxymethyl)glutathione dehydrogenase activity
- benzaldehyde dehydrogenase activity
- retinol binding
- oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor