MAGEE1 Gene Summary [Human]
This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to cognitive disability. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | MAGEE1 |
| Official Name | MAGE family member E1 [Source:HGNC Symbol;Acc:HGNC:24934] |
| Ensembl ID | ENSG00000198934 |
| Bio databases IDs | |
| Aliases | MAGE family member E1 |
| Synonyms | DAMAGE, HCA1, MAGE family member E1, mMage-e1, RGD1560259 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAGEE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MAGE homology domain
- protein binding
- Metaviral_G glycoprotein
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- Nucleus
- postsynaptic membrane
- dendrites
- neuromuscular synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAGEE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- perinuclear region of cytoplasm
- postsynaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding