PLPP4 Gene Summary [Human]
Enables diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to be located in plasma membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLPP4 |
| Official Name | phospholipid phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:23531] |
| Ensembl ID | ENSG00000203805 |
| Bio databases IDs | |
| Aliases | phospholipid phosphatase 4, diacylglycerol pyrophosphate phosphatase-like 2 |
| Synonyms | C030048B12Rik, DPPL2, Gm1090, phospholipid phosphatase 4, PPAPDC1, PPAPDC1A, RGD1306289 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLPP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- diacylglycerol pyrophosphate phosphatase
- PAP2 superfamily
- phosphatidate phosphatase
- phosphatase
- protein binding
- PAP2_like
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLPP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- regulation of calcium ion import
- blastocyst hatching
- Fc-gamma receptor signaling pathway involved in phagocytosis
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- identical protein binding
- protein binding
- diacylglycerol diphosphate phosphatase activity