Plpp4 Gene Summary [Mouse]
Predicted to enable diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Acts upstream of or within blastocyst hatching. Predicted to be active in membrane. Is expressed in early conceptus and secondary oocyte. Orthologous to human PLPP4 (phospholipid phosphatase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plpp4 |
| Official Name | phospholipid phosphatase 4 [Source:MGI Symbol;Acc:MGI:2685936] |
| Ensembl ID | ENSMUSG00000070366 |
| Bio databases IDs | |
| Aliases | phospholipid phosphatase 4 |
| Synonyms | C030048B12Rik, DPPL2, Gm1090, phospholipid phosphatase 4, PPAPDC1, PPAPDC1A, RGD1306289 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plpp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- diacylglycerol pyrophosphate phosphatase
- PAP2 superfamily
- phosphatidate phosphatase
- phosphatase
- protein binding
- PAP2_like
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plpp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- regulation of calcium ion import
- blastocyst hatching
- Fc-gamma receptor signaling pathway involved in phagocytosis
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- identical protein binding
- protein binding
- diacylglycerol diphosphate phosphatase activity