BIK Gene Summary [Human]
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | BIK |
| Official Name | BCL2 interacting killer [Source:HGNC Symbol;Acc:HGNC:1051] |
| Ensembl ID | ENSG00000100290 |
| Bio databases IDs | |
| Aliases | BCL2 interacting killer, natural born killer |
| Synonyms | BBC1, BCL2-interacting killer, BIKLK, BIP1, Blk, BP4, NBK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BIK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Bcl-2 homology 3 domain
- transmembrane domain
- protein domain specific binding
- protein binding
- Bcl2-interacting killer, BH3-domain containing
Pathways
Biological processes and signaling networks where the BIK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- HER2 negative hormone receptor negative breast cancer
- uterine serous papillary cancer
- severe combined immunodeficiency
- primary sclerosing cholangitis
- azoospermia
role in cell
- differentiation
- survival
- cell death
- condensation
- proliferation
- activation
- quantity
- apoptosis
- autophagy in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial envelope
- intracellular membranes
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- mitochondrial membrane
- mitochondrial outer membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BIK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic mitochondrial changes
- male gonad development
- apoptotic process
- positive regulation of release of cytochrome c from mitochondria
- regulation of apoptotic process
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- Bcl-2 family protein complex
- endomembrane system
Molecular Function
What the gene product does at the molecular level
- protein binding