ZBTB12 Gene Summary [Human]
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZBTB12 |
| Official Name | zinc finger and BTB domain containing 12 [Source:HGNC Symbol;Acc:HGNC:19066] |
| Ensembl ID | ENSG00000204366 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 12 |
| Synonyms | Bat-9, C6orf46, D6S59E, G10, NG35, zinc finger and BTB domain containing 12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBTB12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- double-stranded DNA binding
- Zinc-finger double domain
- C2H2-type zinc-finger domain
- BTB_POZ
- BTB/POZ domain
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the ZBTB12 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBTB12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cytokine production
- regulation of immune system process
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription