Zbtb12 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB12 (zinc finger and BTB domain containing 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb12 |
| Official Name | zinc finger and BTB domain containing 12 [Source:MGI Symbol;Acc:MGI:88133] |
| Ensembl ID | ENSMUSG00000049823 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 12 |
| Synonyms | Bat-9, C6orf46, D6S59E, G10, NG35, zinc finger and BTB domain containing 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbtb12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- double-stranded DNA binding
- Zinc-finger double domain
- C2H2-type zinc-finger domain
- BTB_POZ
- BTB/POZ domain
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the Zbtb12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Communication between Innate and Adaptive Immune Cells
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- Neuroinflammation Signaling Pathway
- Nur77 Signaling in T Lymphocytes
- Phagosome Maturation
- Protein Ubiquitination Pathway
- T Cell Receptor Signaling
- Virus Entry via Endocytic Pathways
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbtb12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cytokine production
- regulation of immune system process
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription