CSNK2B Gene Summary [Human]
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CSNK2B |
| Official Name | casein kinase 2 beta [Source:HGNC Symbol;Acc:HGNC:2460] |
| Ensembl ID | ENSG00000204435 |
| Bio databases IDs | |
| Aliases | casein kinase 2 beta |
| Synonyms | casein kinase 2 beta, casein kinase 2, beta polypeptide, casein kinase 2 β, casein kinase 2, β polypeptide, Casein kinase ii β subunit, Ck2, CK2B, ck2 Beta Subunit, CK2N, Ck2 β, ck2 β Subunit, Ckb1, Ckb2, CK II beta, Ck II Beta Subunit, CK II β, Ck II β Subunit, CSK2B, G5A, POBINDS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSNK2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- acidic loop domain
- protein kinase
- positive regulatory domain
- protein binding activity, bridging
- transcription factor binding
- chromatin binding
- protein domain specific binding
- protein binding
- receptor binding
- Casein kinase II regulatory subunit
- identical protein binding
- kinase
- destruction box
- ribonucleoprotein binding
- zinc finger domain
Pathways
Biological processes and signaling networks where the CSNK2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- systemic lupus erythematosus
- tumorigenesis
- Poirier-Bienvenu neurodevelopmental syndrome
- hereditary disorder
- growth failure
- neurodevelopmental disorder
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- intellectual disability and seizures
role in cell
- formation
- formation in
- phosphorylation in
- upregulation in
- expression in
- downregulation in
- degradation in
- proliferation
- colony formation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cell periphery
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear matrix
- nerve ending
- synapse
- cellular protrusions
- PML nuclear bodies
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSNK2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of blood vessel endothelial cell migration
- macromolecular complex assembly
- signal transduction
- negative regulation of cell proliferation
- endothelial tube morphogenesis
- regulation of DNA binding
- disassembly by symbiont of host cell PML body
- positive regulation of activin receptor signaling pathway
- Wnt receptor signaling pathway
- positive regulation of SMAD protein import into nucleus
- adiponectin-mediated signaling pathway
- peptidyl-threonine phosphorylation
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- PML body
- extracellular region
- chromatin
- plasma membrane
- nucleoplasm
- nucleus
- protein kinase CK2 complex
- extracellular vesicular exosome
- cytoplasm
- PcG protein complex
- cytosol
- secretory granule lumen
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding
- metal ion binding
- chromatin binding
- protein kinase regulator activity
- protein serine/threonine kinase activity
- receptor binding
- protein binding, bridging