MICB Gene Summary [Human]
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | MICB |
| Official Name | MHC class I polypeptide-related sequence B [Source:HGNC Symbol;Acc:HGNC:7091] |
| Ensembl ID | ENSG00000204516 |
| Bio databases IDs | |
| Aliases | MHC class I polypeptide-related sequence B |
| Synonyms | MHC class I polypeptide-related sequence B, PERB11.2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MICB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin C1-set domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- immunoglobulin domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the MICB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- papillary thyroid carcinoma
- papillary thyroid cancer
- androgenic alopecia
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- allergic asthma
- inguinal hernia
- asthma
- irritable bowel syndrome
regulates
- HCST
- KLRK1
role in cell
- activation
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MICB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gamma-delta T cell activation
- adaptive immune response
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib
- response to oxidative stress
- response to retinoic acid
- response to heat
- immune response
- immune response-activating cell surface receptor signaling pathway
- killing of cells of other organism
- positive regulation of T cell mediated cytotoxicity
- negative regulation of defense response to virus by host
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- peptide antigen binding
- natural killer cell lectin-like receptor binding
- receptor binding