KLRK1 Gene Summary [Human]
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | KLRK1 |
| Official Name | killer cell lectin like receptor K1 [Source:HGNC Symbol;Acc:HGNC:18788] |
| Ensembl ID | ENSG00000213809 |
| Bio databases IDs | |
| Aliases | killer cell lectin like receptor K1 |
| Synonyms | CD314, D12S2489E, D6H12S2489E, killer cell lectin like receptor K1, killer cell lectin-like receptor subfamily K, member 1, KLR, NK cell receptor D, NKG2-D, NKG2D type II receptor, Nkrp2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLRK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- MHC class I protein binding
- kinase binding
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- ectodomain
- transmembrane domain
- Lectin C-type domain
- protein binding
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the KLRK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- ovalbumin-induced arthritis
- plasma cell myeloma
- prostate cancer
- insulin-dependent diabetes mellitus
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- hypoplasia
- chronic graft-vs-host disease
- arthropathy
role in cell
- apoptosis
- expression in
- formation
- differentiation
- quantity
- phosphorylation in
- proliferation
- chemotaxis
- activation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- extracellular vesicles
- cell surface
- cellular membrane
- immunological synapses
- plasma membrane extracellular face
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLRK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of GTPase activity
- positive regulation of nitric oxide biosynthetic process
- T cell costimulation
- signal transduction
- adaptive immune response
- natural killer cell mediated cytotoxicity
- positive regulation of natural killer cell mediated cytotoxicity
- stimulatory C-type lectin receptor signaling pathway
- cellular response to lipopolysaccharide
- positive regulation of interferon-gamma production
- cell differentiation
- natural killer cell activation
- negative regulation of natural killer cell chemotaxis
- nitric oxide biosynthetic process
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- MHC class Ib receptor activity
- signaling receptor activity
- MHC class I protein binding
- carbohydrate binding