MYL9 Gene Summary [Human]
Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MYL9 |
| Official Name | myosin light chain 9 [Source:HGNC Symbol;Acc:HGNC:15754] |
| Ensembl ID | ENSG00000101335 |
| Bio databases IDs | |
| Aliases | myosin light chain 9, myosin regulatory light chain 2, smooth muscle isoform, myosin regulatory light chain 1 |
| Synonyms | LC20, MLC2, Mlc20, MLC-2C, Mlc-c, MMIHS4, MRLC1, Mylc2c, myosin light chain 9, myosin, light polypeptide 9, regulatory, MYOSIN REGULATORY LIGHT CHAIN 2, SMOOTH MUSCLE isoform, MYRL2, RLC, RLC-C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYL9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- EF-hand, calcium binding motif
- EF-hand domain
- structural constituent of muscle
- structural constituent of cytoskeleton
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- EFh
- protein binding
Pathways
Biological processes and signaling networks where the MYL9 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- PAK Signaling
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- familial platelet disorder with predisposition to acute myelogenous leukemia
- urothelial bladder carcinoma
- lung adenocarcinoma
- prostate cancer
- epithelial cancer
- lung squamous cell carcinoma
- transitional cell bladder cancer
- gastric cancer
- endometrial cancer
role in cell
- expression in
- growth
- quantity
- migration
- phosphorylation in
- epithelial-mesenchymal transition
- aggregation
- formation
- invasion by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- apical compartment
- Mitochondria
- contractile rings
- cytosol
- myosin stress fibers
- Z line
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYL9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myofibril assembly
- regulation of muscle contraction
- platelet aggregation
Cellular Component
Where in the cell the gene product is active
- Z disc
- muscle myosin complex
- cytoplasm
- cell cortex
- stress fiber
- cytosol
- myofibril
Molecular Function
What the gene product does at the molecular level
- structural constituent of muscle
- calcium ion binding
- myosin heavy chain binding