PVRIG Gene Summary [Human]
Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | PVRIG |
| Official Name | PVR related immunoglobulin domain containing [Source:HGNC Symbol;Acc:HGNC:32190] |
| Ensembl ID | ENSG00000213413 |
| Bio databases IDs | |
| Aliases | PVR related immunoglobulin domain containing, CD112 receptor, nectin-2 receptor |
| Synonyms | AABR07035561.2, C7orf15, CD112R, Gm36869, poliovirus receptor related immunoglobulin domain containing, PVR related immunoglobulin domain containing |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PVRIG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- immunoglobulin domain
- protein binding
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PVRIG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein binding
- signaling receptor activity