SEC11A Gene Summary [Human]
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Details
| Type | Retained Intron |
| Official Symbol | SEC11A |
| Official Name | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] |
| Ensembl ID | ENSG00000140612 |
| Bio databases IDs | |
| Aliases | SEC11 homolog A, signal peptidase complex subunit, signal peptidase complex 18 |
| Synonyms | 1810012E07Rik, Endopeptidase SP18, Microsomal signal peptidase 18 kda, SEC11 homolog A, signal peptidase complex subunit, SEC11L1, sid2895, Sid2895p, SPC18, SPCS4A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEC11A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- serine endopeptidase
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- epithelial cancer
- bipolar disorder
- melanoma cancer
- liver cirrhosis
- astrocytoma
- glioma formation
- cardiomyopathy
- glioblastoma
- glioblastoma cancer
regulates
role in cell
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEC11A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal peptide processing
- response to virus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- signal peptidase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- peptidase activity