ADAT3 Gene Summary [Human]
This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | ADAT3 |
| Official Name | adenosine deaminase tRNA specific 3 [Source:HGNC Symbol;Acc:HGNC:25151] |
| Ensembl ID | ENSG00000213638 |
| Bio databases IDs | |
| Aliases | adenosine deaminase tRNA specific 3, tRNA-specific adenosine deaminase 3 homolog (S. cerevisiae) |
| Synonyms | A430024H01Rik, adenosine deaminase tRNA specific 3, adenosine deaminase, tRNA-specific 3, FWP005, MRT36, MST121, MSTP121, NEDBGF, S863-5, TAD3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADAT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytidine_deaminase-like
- Cytidine and deoxycytidylate deaminase zinc-binding region
- adenosine deaminase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADAT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- tRNA-specific adenosine-34 deaminase activity