Adat3 Gene Summary [Mouse]
Predicted to enable catalytic activity and metal ion binding activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA processing. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adat3 |
| Official Name | adenosine deaminase, tRNA-specific 3 [Source:MGI Symbol;Acc:MGI:1924344] |
| Ensembl ID | ENSMUSG00000113640 |
| Bio databases IDs | |
| Aliases | adenosine deaminase, tRNA-specific 3 |
| Synonyms | A430024H01Rik, adenosine deaminase tRNA specific 3, adenosine deaminase, tRNA-specific 3, FWP005, MRT36, MST121, MSTP121, NEDBGF, S863-5, TAD3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytidine_deaminase-like
- Cytidine and deoxycytidylate deaminase zinc-binding region
- adenosine deaminase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- tRNA-specific adenosine-34 deaminase activity