LTB4R2 Gene Summary [Human]
Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LTB4R2 |
| Official Name | leukotriene B4 receptor 2 [Source:HGNC Symbol;Acc:HGNC:19260] |
| Ensembl ID | ENSG00000213906 |
| Bio databases IDs | |
| Aliases | leukotriene B4 receptor 2 |
| Synonyms | 5830462O07Rik, BLT2, BLTR2, JULF2, KPG 004, leukotriene B4 receptor 2, NOP9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LTB4R2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- leukotriene receptor
- seven-transmembrane G protein-coupled receptor superfamily
- leukotriene B4 receptor
Pathways
Biological processes and signaling networks where the LTB4R2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- advanced cancer
- immunodeficiency
- endometriosis
- tumorigenesis
- thermal hyperalgesia
- lung metastasis
- lung cancer
- thoracic cancer
role in cell
- expression in
- production in
- phosphorylation in
- apoptosis
- chemotaxis
- migration
- epithelial-mesenchymal transition
- invasiveness
- formation by
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- lateral cell surfaces
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LTB4R2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of adenylate cyclase activity
- chemotaxis
- neuropeptide signaling pathway
- keratinocyte migration
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- leukotriene receptor activity
- G-protein coupled peptide receptor activity
- leukotriene B4 receptor activity