LYRM4 Gene Summary [Human]
The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | LYRM4 |
| Official Name | LYR motif containing 4 [Source:HGNC Symbol;Acc:HGNC:21365] |
| Ensembl ID | ENSG00000214113 |
| Bio databases IDs | |
| Aliases | LYR motif containing 4 |
| Synonyms | C6orf149, CGI-203, COXPD19, Gm903, ISD11, LYR motif containing 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LYRM4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complex 1 protein (LYR family)
- protein homodimerization
- protein binding
- structural molecule
- LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily
Pathways
Biological processes and signaling networks where the LYRM4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial matrix
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LYRM4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- [2Fe-2S] cluster assembly
- [4Fe-4S] cluster assembly
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity