MAEA Gene Summary [Human]
This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | MAEA |
| Official Name | macrophage erythroblast attacher, E3 ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:13731] |
| Ensembl ID | ENSG00000090316 |
| Bio databases IDs | |
| Aliases | macrophage erythroblast attacher, E3 ubiquitin ligase, GID complex subunit 9, FYV10 homolog (S. cerevisiae) |
| Synonyms | 1110030D19Rik, EMLP, EMP, GID9, HLC-10, LOC101928676, macrophage erythroblast attacher, macrophage erythroblast attacher, E3 ubiquitin ligase, P44EMLP, PIG5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAEA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTLH/CRA C-terminal to LisH motif domain
- CT11-RanBPM
- actin binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- C-terminal to LisH motif
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- spindle apparatus
- cytoskeleton
- Cytoplasm
- cellular membrane
- actin cytoskeleton
- Nucleus
- contractile rings
- cytosol
- nucleoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAEA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- proteasomal ubiquitin-dependent protein catabolic process
- cytoskeleton organization
- negative regulation of myeloid cell apoptotic process
- enucleate erythrocyte development
- cell adhesion
- regulation of mitotic cell cycle
- erythrocyte maturation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- ubiquitin ligase complex
- actomyosin contractile ring
- cytoplasm
- spindle
- nuclear matrix
- plasma membrane
- GID complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- actin binding
- metal ion binding