GCGR Gene Summary [Human]
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Details
| Type | Retained Intron |
| Official Symbol | GCGR |
| Official Name | glucagon receptor [Source:HGNC Symbol;Acc:HGNC:4192] |
| Ensembl ID | ENSG00000215644 |
| Bio databases IDs | |
| Aliases | glucagon receptor |
| Synonyms | GGR, GL-R, glucagon receptor, GR, MVAH |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GCGR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- intracellular loop
- guanyl-nucleotide exchange factor
- extracellular loop
- glucagon receptor
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the GCGR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- liver cancer
- epithelial cancer
- epithelial neoplasia
- pancreatic neoplasia
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- insulin-dependent diabetes mellitus
- adenoma formation
- benign neoplasia
role in cell
- apoptosis
- binding in
- accumulation in
- proliferation
- cell death
- differentiation
- number
- abnormal morphology
- exocytosis by
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- endosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GCGR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- response to starvation
- cell surface receptor signaling pathway
- response to nutrient
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular response to starvation
- regulation of blood pressure
- exocytosis
- hormone-mediated signaling pathway
- cellular response to glucagon stimulus
- positive regulation of gene expression
- glucose homeostasis
- regulation of glycogen metabolic process
Cellular Component
Where in the cell the gene product is active
- endosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glucagon receptor activity
- guanyl-nucleotide exchange factor activity
- peptide hormone binding