GRK3 Gene Summary [Human]
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GRK3 |
| Official Name | G protein-coupled receptor kinase 3 [Source:HGNC Symbol;Acc:HGNC:290] |
| Ensembl ID | ENSG00000100077 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor kinase 3 |
| Synonyms | 4833444A01RIK, ADRBK2, AI851927, AW551196, BARK2, FLJ31125, G protein-coupled receptor kinase 3, β ark2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- G beta gamma protein binding domain
- Protein tyrosine and serine/threonine kinase
- RGS homology domain
- G-protein-coupled receptor binding
- beta-adrenergic-receptor kinase
- Regulator of G protein signaling (RGS) domain superfamily
- protein binding
- Pleckstrin homology-like domain
- Protein kinase domain
- kinase
- Regulator of G protein signaling domain
- Serine/Threonine protein kinases, catalytic domain
- G-protein coupled receptor kinase
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- PH domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the GRK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- HER2 negative hormone receptor negative breast cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- coronary artery disease
- Paget disease of bone
- diffuse type gastric adenocarcinoma
- diffuse gastric carcinoma formation
- intestinal gastric adenocarcinoma
role in cell
- invasion by
- phosphorylation in
- quantity
- expression in
- production in
- binding in
- degranulation
- colony formation by
- osteoclastogenesis
- desensitization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- perinuclear region
- Plasma Membrane
- cytosol
- sperm midpiece
- dendritic spines
- Z line
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- dendritic shafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- desensitization of G-protein coupled receptor protein signaling pathway
- G-protein coupled receptor signaling pathway
- signal transduction
- protein phosphorylation
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- cytosol
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- ATP binding
- protein binding
- beta-adrenergic receptor kinase activity
- G-protein coupled receptor kinase activity
- protein kinase activity