DLEU2 Gene Summary [Human]
This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | DLEU2 |
| Official Name | deleted in lymphocytic leukemia 2 [Source:HGNC Symbol;Acc:HGNC:13748] |
| Ensembl ID | ENSG00000231607 |
| Bio databases IDs | |
| Aliases | deleted in lymphocytic leukemia 2, non-protein coding RNA 22, long intergenic non-protein coding RNA 22, mir-15a-16-1 cluster host gene (non-protein coding) |
| Synonyms | 4932411A06RIK, 7730401J12RIK, BCMSUN, deleted in lymphocytic leukaemia 2, deleted in lymphocytic leukemia 2, DLB2, LEU2, LINC00022, MIR15AHG, NCRNA00022, RFP2, RFP2OS, TRIM13OS |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- chronic lymphocytic leukemia
- neoplasia
- idiopathic pulmonary fibrosis
- oral cancer
- endometrial cancer
- cytogenetically normal acute myeloid leukemia
role in cell
- production in
- expression in
- apoptosis
- phosphorylation in
- invasion by
- migration
- proliferation
- epithelial-mesenchymal transition
- morphology
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown