PPIL3 Gene Summary [Human]
This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPIL3 |
| Official Name | peptidylprolyl isomerase like 3 [Source:HGNC Symbol;Acc:HGNC:9262] |
| Ensembl ID | ENSG00000240344 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase like 3, Cyclophilin J |
| Synonyms | 2310076N22RIK, 2510026K04Rik, CYP10L, CYPJ, peptidylprolyl isomerase (cyclophilin)-like 3, peptidylprolyl isomerase like 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidylprolyl isomerase
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein peptidyl-prolyl isomerization
- protein folding
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- catalytic step 2 spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- protein binding