PISD Gene Summary [Human]
The protein encoded by this gene catalyzes the conversion of phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane. The encoded protein is active in phospholipid metabolism and interorganelle trafficking of phosphatidylserine. [provided by RefSeq, May 2016]
Details
| Type | Protein Coding |
| Official Symbol | PISD |
| Official Name | phosphatidylserine decarboxylase [Source:HGNC Symbol;Acc:HGNC:8999] |
| Ensembl ID | ENSG00000241878 |
| Bio databases IDs | |
| Aliases | phosphatidylserine decarboxylase |
| Synonyms | 9030221M09RIK, DJ858B16, dJ858B16.2, LIBF, LOC683500, phosphatidylserine decarboxylase, PSD, PSDC, PSSC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PISD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylserine decarboxylase
- phosphatidylserine decarboxylase precursor
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- Liberfarb syndrome
- head and neck neuroendocrine neoplasia
- pituitary gland adenoma
- PISD-related mitochondrial disease
- chronic lymphocytic leukemia
role in cell
- molecular cleavage in
- formation
- morphology
- transformation
- organization
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Golgi Apparatus
- Mitochondria
- lipid droplets
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PISD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial protein catabolic process
- phosphatidylethanolamine biosynthetic process
- protein autoprocessing
- regulation of mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- mitochondrion
- cytosol
- Golgi apparatus
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine decarboxylase activity