RIPK4 Gene Summary [Human]
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RIPK4 |
| Official Name | receptor interacting serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:496] |
| Ensembl ID | ENSG00000183421 |
| Bio databases IDs | |
| Aliases | receptor interacting serine/threonine kinase 4, protein kinase C-associated kinase, PKC-delta-interacting protein kinase |
| Synonyms | 2310069J12Rik, ANKK2, ANKRD3, CHANDS, DIK, NKRD3, PKK, PPS2, receptor interacting serine/threonine kinase 4, receptor-interacting serine-threonine kinase 4, RIP4, Ripk4 predicted |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RIPK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Ankyrin repeats (many copies)
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- Ankyrin repeats (3 copies)
- protein binding
- Protein kinase domain
- activation loop
- Ankyrin repeat
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epidermal hyperplasia
- organismal death
- metastasis
- CHAND syndrome
- atresia
- lethal popliteal pterygium syndrome
- esophageal atresia
- cleft palate
- parakeratosis
- rotator cuff injury
role in cell
- activation in
- expression in
- phosphorylation in
- proliferation
- growth
- binding in
- differentiation
- abnormal morphology
- serine phosphorylation in
- deubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- intracellular membranes
- Plasma Membrane
- membrane compartment
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RIPK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- morphogenesis of an epithelium
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity