Pisd Gene Summary [Mouse]
Predicted to enable phosphatidylserine decarboxylase activity. Predicted to be involved in several processes, including lipid droplet formation; mitochondrial protein catabolic process; and phosphatidylethanolamine biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PISD (phosphatidylserine decarboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pisd |
| Official Name | phosphatidylserine decarboxylase [Source:MGI Symbol;Acc:MGI:2445114] |
| Ensembl ID | ENSMUSG00000023452 |
| Bio databases IDs | |
| Aliases | phosphatidylserine decarboxylase |
| Synonyms | 9030221M09RIK, DJ858B16, dJ858B16.2, LIBF, LOC683500, phosphatidylserine decarboxylase, PSD, PSDC, PSSC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pisd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylserine decarboxylase
- phosphatidylserine decarboxylase precursor
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- Liberfarb syndrome
- head and neck neuroendocrine neoplasia
- pituitary gland adenoma
- PISD-related mitochondrial disease
- chronic lymphocytic leukemia
role in cell
- molecular cleavage in
- formation
- morphology
- transformation
- organization
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Golgi Apparatus
- Mitochondria
- lipid droplets
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pisd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial protein catabolic process
- phosphatidylethanolamine biosynthetic process
- protein autoprocessing
- regulation of mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- mitochondrion
- cytosol
- Golgi apparatus
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine decarboxylase activity