NME2 Gene Summary [Human]
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | NME2 |
| Official Name | NME/NM23 nucleoside diphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:7850] |
| Ensembl ID | ENSG00000243678 |
| Bio databases IDs | |
| Aliases | NME/NM23 nucleoside diphosphate kinase 2 |
| Synonyms | NDKB, NDPK2, NDPK-B, NDP KINASE B, nm23-2, NM23B, NM23-H2, NME/NM23 nucleoside diphosphate kinase 2, NUCLEOSIDE DIPHOSHATE KINASE, Nucleoside diphosphate kinase alpha, Nucleoside diphosphate kinase α, p18-12d, PUF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NME2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intermediate filament binding
- nucleoside diphosphate kinase
- protein serine/threonine kinase
- transcription co-activator
- fatty acid binding
- enzyme binding
- protein binding
- identical protein binding
- DNA binding
- kinase
- binding protein
- Nucleoside diphosphate kinase family
- GDP binding
- NDPk
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- breast cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- Dukes stage C colorectal cancer
role in cell
- colony formation
- proliferation
- apoptosis
- expression in
- phosphorylation in
- migration
- growth
- adhesion
- differentiation
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- ruffle
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cell periphery
- perinuclear region
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- intermediate filaments
- cytosol
- mitochondrial membrane
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NME2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte differentiation
- CTP biosynthetic process
- GTP biosynthetic process
- nucleoside triphosphate biosynthetic process
- regulation of apoptotic process
- cell adhesion
- positive regulation of transcription from RNA polymerase II promoter
- integrin-mediated signaling pathway
- UTP biosynthetic process
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- regulation of epidermis development
- positive regulation of epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- ruffle
- cytosol
- secretory granule lumen
- extracellular region
- cell periphery
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- protein binding
- transcription coactivator activity
- G-quadruplex DNA binding
- metal ion binding
- GDP binding
- nucleoside diphosphate kinase activity
- protein histidine kinase activity