PDGFA Gene Summary [Human]
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | PDGFA |
| Official Name | platelet derived growth factor subunit A [Source:HGNC Symbol;Acc:HGNC:8799] |
| Ensembl ID | ENSG00000197461 |
| Bio databases IDs | |
| Aliases | platelet derived growth factor subunit A, PDGF A-chain, platelet-derived growth factor alpha chain |
| Synonyms | PDGF-1, Pdgf a-chain, PDGFACP, PDGF alpha, PDGF α, platelet derived growth factor, alpha, platelet derived growth factor subunit A, platelet derived growth factor, α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDGFA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PDGF
- Platelet-derived growth factor, N terminal region
- platelet-derived growth factor receptor binding
- collagen binding
- protein homodimerization
- protein binding
- identical protein binding
- growth factor
- growth factor binding
- protein heterodimerization
Pathways
Biological processes and signaling networks where the PDGFA gene in human plays a role, providing insight into its function and relevance in health or disease.
- Atherosclerosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Macropinocytosis Signaling
- PAK Signaling
- PDGF Signaling
- PPAR Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of PKR in Interferon Induction and Antiviral Response
- Sphingosine-1-phosphate Signaling
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- pulmonary emphysema
- androgenic alopecia
- endometriosis
- alopecia
- osteoporosis
- respiratory failure
- metastatic colorectal cancer
- growth failure
- single suture craniosynostosis
role in cell
- invasion by
- migration
- expression in
- phosphorylation in
- proliferation
- organization
- quantity
- number
- formation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- cell surface
- endoplasmic reticulum lumen
- Golgi membrane
- alpha granules
- cytoplasmic vesicles
- microvilli
- perikaryon
- axons
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDGFA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
- negative chemotaxis
- cell projection assembly
- positive regulation of cell proliferation
- response to wounding
- skin development
- lung alveolus development
- regulation of peptidyl-tyrosine phosphorylation
- positive regulation of protein autophosphorylation
- wound healing
- positive regulation of cell division
- hair follicle development
- regulation of glomerular mesangial cell proliferation
- angiogenesis
- positive regulation of fibroblast proliferation
- negative regulation of phosphatidylinositol biosynthetic process
- regulation of DNA biosynthetic process
- regulation of smooth muscle cell migration
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
- platelet-derived growth factor receptor-alpha signaling pathway
- cell-cell signaling
- platelet-derived growth factor receptor signaling pathway
- positive regulation of mesenchymal cell proliferation
- positive regulation of MAPK cascade
- organ morphogenesis
- cell activation
- regulation of actin cytoskeleton organization
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of platelet activation
- actin cytoskeleton organization
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- extracellular space
- microvillus
- Golgi membrane
- extracellular region
- Golgi lumen
- cell surface
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein homodimerization activity
- protein binding
- platelet-derived growth factor receptor binding
- collagen binding
- protein heterodimerization activity
- platelet-derived growth factor binding