TTC4 Gene Summary [Human]
This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | TTC4 |
| Official Name | tetratricopeptide repeat domain 4 [Source:HGNC Symbol;Acc:HGNC:12394] |
| Ensembl ID | ENSG00000243725 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat domain 4 |
| Synonyms | 2810002P21Rik, CNS1, L62, LOC100129188, tetratricopeptide repeat domain 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TTC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- CTWD_Cns1-like
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TTC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- defense response to virus
- protein folding
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- Hsp90 protein binding
- Hsp70 protein binding