JMJD7 Gene Summary [Human]
This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | JMJD7 |
| Official Name | jumonji domain containing 7 [Source:HGNC Symbol;Acc:HGNC:34397] |
| Ensembl ID | ENSG00000243789 |
| Bio databases IDs | |
| Aliases | jumonji domain containing 7 |
| Synonyms | jumonji domain containing 7, LOC100131005 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JMJD7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- endopeptidase
- 2-oxoglutarate:oxygen oxidoreductase
- peptidase
- aminopeptidase
- monooxygenase
- enzyme
- protein binding
- RmlC-like cupin superfamily
- Cupin-like domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JMJD7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- protein hydroxylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- methylated histone residue binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
- endopeptidase activity
- aminopeptidase activity
- monooxygenase activity