FCGR2C Gene Summary [Human]

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]

Details

Type
Processed Transcript
Official Symbol
FCGR2C
Official Name
Fc fragment of IgG receptor IIc (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:15626]
Ensembl ID
ENSG00000244682
Bio databases IDs NCBI: 9103 Ensembl: ENSG00000244682
Aliases Fc fragment of IgG receptor IIc (gene/pseudogene), Fc gamma receptor IIc (gene/pseudogene)
Synonyms CD32, CD32C, CDW32, FCG2, Fc gamma receptor IIc (gene/pseudogene), FcgammaRIIc, FCRIIC, Fc γ receptor IIc (gene/pseudogene), IGFR2
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCGR2C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • immunoglobulin domain
  • Immunoglobulin like
  • Immunoglobulin I-set domain
  • protein binding
  • transmembrane receptor
  • T-cell surface glycoprotein CD3 delta chain

Pathways

Biological processes and signaling networks where the FCGR2C gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • Alzheimer disease
  • bacteremia
  • infection
  • schizophrenia
  • HIV infection
  • asthma
  • immunodeficiency
  • septic shock
  • multiple sclerosis
  • transverse myelitis
regulated by
  • IgG
  • NUP98-DDX10
regulates

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human FCGR2C gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • immune response
  • antibody-dependent cellular cytotoxicity
  • Fc-gamma receptor signaling pathway
  • cell surface receptor signaling pathway
  • positive regulation of tumor necrosis factor production
  • positive regulation of phagocytosis

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • membrane
  • external side of plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • transmembrane signaling receptor activity
  • IgG receptor activity
  • IgG binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.