ECSCR Gene Summary [Human]
The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | ECSCR |
| Official Name | endothelial cell surface expressed chemotaxis and apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:35454] |
| Ensembl ID | ENSG00000249751 |
| Bio databases IDs | |
| Aliases | endothelial cell surface expressed chemotaxis and apoptosis regulator, endothelial cell-specific molecule 2, apoptosis regulator through modulating IAP expression |
| Synonyms | 1110006O17Rik, ARIA, Ecscr-ps1, ECSM2, endothelial cell surface expressed chemotaxis and apoptosis regulator, LOC682650 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ECSCR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Endothelial cell-specific chemotaxis regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- atherosclerosis
- cardiac fibrosis
role in cell
- expression in
- cell death
- phosphorylation in
- apoptosis
- formation
- signaling in
- migration
- chemotaxis by
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ECSCR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- chemotaxis
- angiogenesis
- apoptotic process
- cell differentiation
- positive regulation of endothelial cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding