Ecscr Gene Summary [Mouse]
Acts upstream of or within negative regulation of angiogenesis. Located in cytosol and plasma membrane. Is expressed in several structures, including cardiovascular system; gut; hemolymphoid system gland; male reproductive gland or organ; and respiratory system. Orthologous to human ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ecscr |
| Official Name | endothelial cell surface expressed chemotaxis and apoptosis regulator [Source:MGI Symbol;Acc:MGI:1915795] |
| Ensembl ID | ENSMUSG00000073599 |
| Bio databases IDs | |
| Aliases | endothelial cell surface expressed chemotaxis and apoptosis regulator |
| Synonyms | 1110006O17Rik, ARIA, Ecscr-ps1, ECSM2, endothelial cell surface expressed chemotaxis and apoptosis regulator, LOC682650 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ecscr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Endothelial cell-specific chemotaxis regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- atherosclerosis
- cardiac fibrosis
role in cell
- expression in
- cell death
- phosphorylation in
- apoptosis
- formation
- signaling in
- migration
- chemotaxis by
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ecscr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- chemotaxis
- angiogenesis
- apoptotic process
- cell differentiation
- positive regulation of endothelial cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding