PSMA7 Gene Summary [Human]
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | PSMA7 |
| Official Name | proteasome 20S subunit alpha 7 [Source:HGNC Symbol;Acc:HGNC:9536] |
| Ensembl ID | ENSG00000101182 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit alpha 7, proteasome subunit XAPC7, proteasome subunit RC6-1, proteasome subunit α4 |
| Synonyms | 20S PROTEASOME alpha 7 subunit, 20S PROTEASOME α 7 subunit, 26s Proteasome alpha 1, 26s Proteasome α 1, C6, C6-I, HEL-S-276, HSPC, proteasome 20S subunit alpha 7, proteasome 20S subunit α 7, proteasome subunit alpha 7, proteasome subunit α 7, RC6-1, XAPC7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMA7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- Proteasome subunit A N-terminal signature
- peptidase
- Proteasome subunit A N-terminal signature Add an annotation
- proteasome endopeptidase complex, archaeal, alpha subunit
- protein binding
- Proteasome subunit
- identical protein binding
Pathways
Biological processes and signaling networks where the PSMA7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
- late endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMA7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- proteasome core complex, alpha-subunit complex
- cytosol
- proteasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding