RABGAP1L Gene Summary [Human]
Enables GTPase activator activity and small GTPase binding activity. Acts upstream of or within regulation of protein localization. Located in Golgi apparatus; early endosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RABGAP1L |
| Official Name | RAB GTPase activating protein 1 like [Source:HGNC Symbol;Acc:HGNC:24663] |
| Ensembl ID | ENSG00000152061 |
| Bio databases IDs | |
| Aliases | RAB GTPase activating protein 1 like |
| Synonyms | 5830411O09RIK, 8430421H08Rik, 9630005B12Rik, Hh1, HHL, KIAA0471, LOC100506087, LOC100909978, mKIAA0471, RAB GTPase activating protein 1-like, RGD1304620, TBC1D18 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RABGAP1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Kinesin protein
- Domain in Tre-2, BUB2p, and Cdc16p
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- non-small cell lung cancer
- schizophrenia
- migraines
- osteoarthritis
- neuroticism
- endometriosis
- systemic lupus erythematosus
- familial adenomatous polyposis
- metabolic syndrome X
role in cell
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Nucleus
- Golgi Apparatus
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RABGAP1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization
- regulation of GTPase activity
- protein transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- small GTPase binding