PYDC2 Gene Summary [Human]
Involved in several processes, including negative regulation of NLRP3 inflammasome complex assembly; negative regulation of signal transduction; and regulation of gene expression. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PYDC2 |
| Official Name | pyrin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:33512] |
| Ensembl ID | ENSG00000253548 |
| Bio databases IDs | |
| Aliases | pyrin domain containing 2 |
| Synonyms | cPOP2, POP2, pyrin domain containing 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PYDC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAAD/DAPIN/Pyrin domain
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- perinuclear vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PYDC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- negative regulation of NF-kappaB transcription factor activity
- innate immune response
- negative regulation of inflammatory response
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of interleukin-1 beta production
- negative regulation of NLRP3 inflammasome complex assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding