NOX5 Gene Summary [Human]
This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | NOX5 |
| Official Name | NADPH oxidase 5 [Source:HGNC Symbol;Acc:HGNC:14874] |
| Ensembl ID | ENSG00000255346 |
| Bio databases IDs | |
| Aliases | NADPH oxidase 5 |
| Synonyms | NADPH oxidase 5, RP11 809H162 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOX5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- EF-Hand
- core domain, structural
- EF-hand, calcium binding motif
- EF-hand domain pair
- Cytochrome_b_N
- EFh
- protein binding
- ion channel
- superoxide-generating NADPH oxidase
- hydrogen ion channel
- EF-hand domain
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- Oxidoreductase NAD-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- osteoarthritis
- cardiac hypertrophy
- heart failure
- interstitial fibrosis
role in cell
- expression in
- proliferation
- phosphorylation in
- production in
- generation in
- quantity
- migration
- damage in
- hypertrophy
- enlargement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- outer membranes
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- flagella
- Mitochondria
- endoplasmic reticulum membrane
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOX5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- apoptotic process
- endothelial cell proliferation
- regulation of fusion of sperm to egg plasma membrane
- superoxide anion generation
- defense response
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- NADPH oxidase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- NADP binding
- flavin adenine dinucleotide binding
- calcium ion binding
- hydrogen ion channel activity
- superoxide-generating NADPH oxidase activity
- heme binding