CYP2A6 Gene Summary [Human]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CYP2A6 |
| Official Name | cytochrome P450 family 2 subfamily A member 6 [Source:HGNC Symbol;Acc:HGNC:2610] |
| Ensembl ID | ENSG00000255974 |
| Bio databases IDs | |
| Aliases | cytochrome P450 family 2 subfamily A member 6 |
| Synonyms | Coh, CPA6, CPA7, CPAD, Cyp15a1, Cyp15a2, CYP2A, CYP2A3, Cyp2a3a, CYP2A4, Cyp2a4/5, Cyp2a5, CYP2A6, Cyp2a6/7, CYP2A7, CYPIIA5, CYPIIA6, CYPIIA7, cytochrome P450 family 2 subfamily A member 6, cytochrome P450 family 2 subfamily A member 7, cytochrome P450, family 2, subfamily a, polypeptide 3, cytochrome P450, family 2, subfamily a, polypeptide 4, cytochrome P450, family 2, subfamily a, polypeptide 5, D7Ucla4, LOC100504787, P450C2A, P450-IIA4, P450PB, RATCYP2A3A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CYP2A6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- oxygen binding
- unspecific monooxygenase
- monooxygenase
- enzyme binding
- coumarin 7-hydroxylase
- enzyme
- protein binding
- heme binding
Pathways
Biological processes and signaling networks where the CYP2A6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial cancer
- liver cancer
- chronic obstructive pulmonary disease
- nicotine dependence
- lung squamous cell carcinoma
- squamous cell lung cancer
- protection against nicotine dependence
- non-small cell lung carcinoma
- asphyxiation
regulates
- reactive oxygen species
- luciferase reporter gene
- coumarin
- nicotine
- acetaminophen
- nitrogen
- 3-hydroxyacetaminophen
- xenobiotic
- 7-hydroxycoumarin
- (-)-camphor
role in cell
- proliferation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CYP2A6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- coumarin metabolic process
- epoxygenase P450 pathway
- xenobiotic metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- arachidonic acid epoxygenase activity
- iron ion binding
- aromatase activity
- heme binding