NR1I3 Gene Summary [Human]
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
Details
| Type | Protein Coding |
| Official Symbol | NR1I3 |
| Official Name | nuclear receptor subfamily 1 group I member 3 [Source:HGNC Symbol;Acc:HGNC:7969] |
| Ensembl ID | ENSG00000143257 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 1 group I member 3, constitutive androstane receptor |
| Synonyms | CAR, CAR1, CAR2, CAR-beta, Care2, CAR-β, Constitutive androstane receptor, ESTM32, MB67, nuclear receptor subfamily 1 group I member 3, nuclear receptor subfamily 1, group I, member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NR1I3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- dimerization domain
- DNA binding domain
- nucleic acid binding
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- alpha helix
- xenobiotic response sequence
- AF-2 transcription activation domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the NR1I3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cancer
- obesity
- hepatic steatosis
- diabetic nephropathy
- hepatomegaly
- hepatic injury
- survival
- weight loss
- leukopenia
role in cell
- proliferation
- activation in
- binding in
- expression in
- induction in
- apoptosis
- development
- recruitment in
- transactivation in
- beta-oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NR1I3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- signal transduction
- cell differentiation
- osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity