MRC1 Gene Summary [Human]
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | MRC1 |
| Official Name | mannose receptor C-type 1 [Source:HGNC Symbol;Acc:HGNC:7228] |
| Ensembl ID | ENSG00000260314 |
| Bio databases IDs | |
| Aliases | mannose receptor C-type 1, macrophage mannose receptor |
| Synonyms | AW259686, bA541I19.1, CD206, CLEC13D, CLEC13DL, hMR, LOC101060092, macrophage mannose receptor, Mannose R, mannose receptor C-type 1, mannose receptor, C type 1, Mg4sr, MMR, Mmr1, Mr, MRC1L1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil
- cargo receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- carbohydrate recognition domain
- beta-trefoil_Ricin_MRC-like
- protein binding
- FN2
- mannose binding
- transmembrane domain
- Lectin C-type domain
- cytosolic tail domain
- transmembrane receptor
- cysteine rich domain
Pathways
Biological processes and signaling networks where the MRC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymph node-negative breast cancer
- breast cancer
- epithelial cancer
- Alzheimer disease
- obesity
- oral squamous cell carcinoma
- cutaneous melanoma
- insulin-dependent diabetes mellitus
- acute myeloid leukemia
- rheumatoid arthritis
role in cell
- uptake in
- expression in
- production in
- response by
- endocytosis by
- phagocytosis by
- ingestion by
- response
- release in
- uptake
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- endosomal membrane
- early endosomes
- endocytotic vesicle
- peripheral vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MRC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cellular response to lipopolysaccharide
- cellular response to interleukin-4
- cellular response to interferon-gamma
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- endosome membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- mannose binding
- cargo receptor activity
- signaling receptor activity
- viral receptor activity