KLF6 Gene Summary [Human]
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
Details
| Type | Processed Transcript |
| Official Symbol | KLF6 |
| Official Name | Kruppel like factor 6 [Source:HGNC Symbol;Acc:HGNC:2235] |
| Ensembl ID | ENSG00000067082 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 6, KLF transcription factor 6, GC-rich binding factor |
| Synonyms | Aa1017, BCD1, C86813, CBA1, COPEB, CPBP, Erythropoietin 1, FM2, FM6, GBF, Ierepo1, IEREPO3, KLF transcription factor 6, Kruppel-like transcription factor 6, KRUPPEL LIKE ZINC FINGER protein ZF9, PAC1, PROTO-ONCOGENE BCD, Proto-oncogene BCD1, R75280, ST12, ZF9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins
- zinc finger domain
- p53-binding domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the KLF6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- metastasis
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- neoplasia
- tumorigenesis
- fibrosis
- COVID-19
role in cell
- expression in
- transactivation in
- production in
- cell viability
- activation in
- binding in
- degradation in
- proliferation
- transcription in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- positive regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleolus
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity