VTRNA2-1 Gene Summary [Human]
This gene produces an RNA polymerase III transcript that resembles both a component of the ribonucleoprotein vault particle and a pre-microRNA. However, the RNA product does not function as a vault or microRNA; rather, it acts as a direct inhibitor of protein kinase R (also known as eukaryotic translation initiation factor 2-alpha kinase 2, EIF2AK2), and thereby plays an important role in the regulation of cell growth. This gene is located in the vicinity of a differentially methylated region (DMR) and is imprinted and may show allele-specific expression. This gene is also often hypermethylated and repressed in cancers. [provided by RefSeq, Nov 2015]
Details
| Type | Vault RNA (alternative notation) |
| Official Symbol | VTRNA2-1 |
| Official Name | vault RNA 2-1 [Source:HGNC Symbol;Acc:HGNC:37054] |
| Ensembl ID | ENSG00000270123 |
| Bio databases IDs | |
| Aliases | vault RNA 2-1 |
| Synonyms | AC005219.1, CBL-3, hsa-mir-886, hsa-mir-886-3p, hsa-mir-886-5p, hvg-5, MI0005527, MIR886, miR-886-5p, MIRN886, nc886, pre-miR-886, svtRNA2-1a, vault RNA 2-1, VTRNA2 |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical squamous cell carcinoma
- squamous cell cervical cancer
- ulcerative colitis
- Friedreich ataxia
- ALK positive anaplastic large cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- ALK fusion positive cancer
- ALK negative anaplastic large cell lymphoma
- adult T-cell leukemia/lymphoma
role in cell
- proliferation
- expression in
- apoptosis
- activation in
- phosphorylation in
- binding in
- differentiation
- number
- degradation in
- autophosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown