SSB Gene Summary [Human]
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | SSB |
| Official Name | small RNA binding exonuclease protection factor La [Source:HGNC Symbol;Acc:HGNC:11316] |
| Ensembl ID | ENSG00000138385 |
| Bio databases IDs | |
| Aliases | small RNA binding exonuclease protection factor La, La ribonucleoprotein domain family, member 3, Lupus La protein, La autoantigen |
| Synonyms | FIBb-48, La, LA ANTIGEN, LARP3, La/SSB, Lupus la protein homolog, small RNA binding exonuclease protection factor La, SSB-48 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- ribonucleoprotein binding domain
- RNA recognition motif (RRM) superfamily
- La domain
- short basic motif
- ATP-binding domain
- RNA recognition motif
- mRNA binding
- La motif
- walker type A motif
- nuclear localization sequence
- enzyme
- glycine lysine rich domain
- protein binding
- acidic domain
- RNA binding
- poly(U) binding protein
- nuclear retention element
- RNA binding motif
- basic domain
- LA motif RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- astrocytosis
- cervical cancer
- Waldenström macroglobulinemia
- COVID-19
- Sjögren syndrome
- infection by Influenza A virus subtype H1N1
- infection by HIV-1
role in cell
- expression in
- binding in
- apoptosis
- cell death
- accumulation in
- proliferation
- phosphorylation in
- abnormality
- growth in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribonucleoprotein fractions
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- cell surface
- cytosol
- dense fibrillar component
- nucleoplasm
- nucleoli
- nuclear envelope
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SSB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- tRNA processing
- nuclear histone mRNA catabolic process
- tRNA export from nucleus
- tRNA 3'-end processing
- histone mRNA metabolic process
- tRNA 5'-leader removal
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- cytoplasmic stress granule
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- poly(U) RNA binding
- tRNA binding